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KMID : 0616119950260020148
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Korean Journal of Pharmacognosy
1995 Volume.26 No. 2 p.148 ~ p.153
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Studise on the Effect of Aloe spp. On Ethanol Methabolism(Ⅰ)
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신국현/Shin, Kuk Hyun
우원식/송영진/정하숙/이정미/심창섭/Woo, Won Sick/Song, Young Jin/Chung, Ha Sook/Lee, Jung Mi/Shim, Chang Sub
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Abstract
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As an initial step for evaluating hepatoprotective. components against alcohol-induced toxicity, the effect of various; fractions from Aloe vera on alcohol metabolism in rats were examined and the results were as follows: Water soluble fraction, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic ADH activity. On the other hand, the fractions soluble in organic solvent was found to cause an increase in the blood ethanol concentration and inhibit ADH activity. Further fractionation of the water soluble fraction by ultrafiltration system gave four subfractions corresponding to molecular weight and treatment of them in rats demonstrated that subfraction of M.W. > 30,000 exhibited the most potent enhancing activity of ethanol methabolism.
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KEYWORD
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Aloe vera, inhibition and enhancement of ethanol methabolism, ADH
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